Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources

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Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources

BACKGROUND We use silkworms to evaluate therapeutic effects of drug candidates. Our previous reports have revealed that there are common mechanisms of pharmacokinetics of chemicals in silkworms and mammals. In this report, we attempt to establish a method by using silkworms to identify chemicals from plant extracts which are absorbed from intestine and also stably exist in body fluids. RESULT...

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ژورنال

عنوان ژورنال: BMC Pharmacology

سال: 2010

ISSN: 1471-2210

DOI: 10.1186/1471-2210-10-7